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KMID : 0360220180590111024
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Journal of the Korean Ophthalmological Society
2018 Volume.59 No. 11 p.1024 ~ p.1029
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Analysis of 25?Hydroxy Vitamin D in the Aqueous Humor of Age?related Macular Degeneration Patients
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Song Won-Seok
Yoon Won-Tae
Kim Yong-Kyu
Park Sung-Pyo
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Abstract
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Purpose: We examined aqueous humor levels of 25?hydroxyvitamin D (vitamin D) in patients with age?related macular degeneration to investigate possible relationships between aqueous humor vitamin D levels and clinical manifestations.
Methods: Patients > 50 years of age, 52 eyes of 34 patients with age?related macular degeneration, and 23 eyes of 17 patients treated with cataract surgery without retinal disease, were examined for aqueous humor vitamin D levels and compared. The experimental group was divided into two groups according to the median value of aqueous humor vitamin D levels. We compared the clinical manifestations of macular degeneration in both groups and identified relationships between aqueous humor vitamin D levels and clinical features.
Results: Vitamin D levels in the aqueous humor were significantly lower in the experimental group than in the control group (experimental, 10.03 ± 10.1 ng/mL vs. control group, 40.8 ± 16.4 ng/mL; p < 0.001). Patients with high vitamin D levels in the macular degeneration group had a higher percentage of fibrovascular pigment epithelial detachments than those in the low grade group (high grade group, 65% vs. low grade group, 27%; p = 0.003). Multiple linear regression analysis showed a significant correlation between vitamin D levels and the total number of anti?vascular endothelial growth factor intravitreal injections within 6 months (standardize coefficient, β = ?0.336).
Conclusions: Patients with wet age?related macular degeneration had significantly lower vitamin D levels in the aqueous humor compared to control group subjects of similar ages. However, in patients with macular degeneration, low vitamin D levels were associated with a greater number of intravitreal injections, while higher levels of vitamin D may lead to more advanced forms of fibrovascular retinal pigment epithelium and related low vision. These relationships were not always constant, so further studies on the relationships between local vitamin D levels and ocular disorders are needed.
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KEYWORD
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Age?related macular degeneration, Aqueous humor, Vitamin D
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